Oscillatory signal decoding within the ERK cascade.

ABSTRACT: Extracellular-signal-regulated kinase (ERK) integrates multiple growth factor and hormone stimuli to control essential cellular processes such as proliferation, survival, and migration. In electrically excitable cells, the ERK pathway also interfaces with intracellular Ca ²⁺ dynamics to achieve non-canonical, cell-type specific functions, having been implicated in neuronal synaptic plasticity, cardiac hypertrophy, and pancreatic insulin secretion. Yet how the classical Ras/MEK/ERK cascade responds to and decodes dynamic Ca ²⁺ signals at its multiple levels to regulate cellular function is poorly understood. Here, we investigated the dynamics of Ca ²⁺ -induced ERK pathway activation in a pancreatic β-cell line using genetically encoded fluorescent biosensors

SUBMITTER: Ganesan A 

PROVIDER: S-EPMC12324189 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature