Brain-wide coordination of decision formation and commitment.

ABSTRACT: Neural correlates of a subject's upcoming choice in decision making tasks are remarkably widespread throughout the brain, but how these brain-wide signals are coordinated remains unknown. Do brain regions reflect competing or shared decision computations? Are decision signals generated by distributed circuits or are they computed locally and then broadcast broadly? To address these fundamental questions, we took a brain-wide approach, simultaneously recording from thousands of neurons across up to twenty brain regions in rats performing a decision making task requiring gradual accumulation of auditory evidence. This allowed decoding, on single trials and for each of the simultaneously recorded regions, the time-varying state of the decision as it is being formed. We found strong moment-by-

SUBMITTER: Bondy AG 

PROVIDER: S-EPMC12324202 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature