Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.

ABSTRACT:

Background

Cocaine use disorder (CUD) is a major public health crisis with detrimental individual and societal effects. The specific genes mediating CUD remain largely unknown.

Methods

We conducted a genome-wide association study (GWAS) using outbred N/NIH Heterogeneous Stock (HS; n = 836, female = 415, male = 421) rats. We examined multiple CUD-related phenotypes that captured acquisition of self-administration, escalation of intake, and compulsive-like responding.

Results

Consistent with the existing literature, these traits were phenotypically and genetically correlated and exhibited modest heritability (h² = 0.07 - 0.16). We identified six genome-wide significant associations. One locus on chromosome 16 was associated with the variable time between coca

SUBMITTER: Lara MK 

PROVIDER: S-EPMC12324211 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature