Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in <i>Jak2</i> ^<i>V617F</i> Mice.

ABSTRACT:

Background –

The Jak2 ^V617F (Jak2 ^VF ) mutation is an important cause of both clonal hematopoiesis of indeterminate potential (CHIP) and myeloproliferative neoplasms (MPN). Mouse models of Jak2 ^VF CHIP and MPN show accelerated atherosclerosis progression, driven by macrophage inflammasome activation. We undertook the present study to assess the hypothesis that ongoing inflammation would impede atherosclerosis resolution in Jak2 ^VF mice.

Methods and results –

Chimeric Jak2 ^VF/WT or control WT/WT bone marrow was transplanted into Ldlr ^-/- mice and, following 13-16 weeks of Western diet-induced atherosclerosis progression, cholest

SUBMITTER: Hardaway BD 

PROVIDER: S-EPMC12324260 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature