Recurrent connectivity supports carbon dioxide sensitivity in <i>Aedes aegypti</i> mosquitoes.

ABSTRACT: The mosquito Aedes aegypti's human host-seeking behavior depends on the integration of multiple sensory cues. One of these cues, carbon dioxide (CO₂), gates odorant and heat pathways and activates host-seeking behavior. The neuronal circuits underlying processing of CO₂ information remain unclear. We used automated serial-section transmission electron microscopy (EM) to image and reconstruct the circuitry of the glomeruli that are innervated by the Ae. aegypti maxillary palp, including the glomerulus that responds to CO₂. Notably, CO₂-sensitive olfactory sensory neurons (OSNs) make high levels of recurrent synaptic connections with one another, while making a low density of feedforward synapses. At some of these contacts between CO<

SUBMITTER: Bao J 

PROVIDER: S-EPMC12324267 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature