Polyunsaturated fatty acids promote appetite via the microbiome-gut-brain axis.

ABSTRACT: Appetite is regulated by nutrient-sensing systems that integrate long-term signals from energy stores and short-term cues from dietary intake, yet this regulation is increasingly disrupted by industrialized diets. Although the physiological effects of industrialized diets are well documented, the continued rise in metabolic and eating disorders underscores a critical gap in our understanding of how these diets shape neural regulation of eating behavior. Here, we tested how distinct properties of industrialized diets alter brain neurochemistry and change appetite. We probed the properties of an industrialized diet through contrasts targeting the overall diet pattern (Western vs. control), enriched macronutrients (fat vs. sugar), and isocaloric trade-offs of macronutrient variants (saturated

SUBMITTER: Liow YJ 

PROVIDER: S-EPMC12324272 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature