Gasdermin E is Dispensable for H1N1 Influenza Virus Pathogenesis in Mice.

ABSTRACT: Targeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in regulating influenza virus infection outcomes. We found that Gsdme ^-/- mice showed similar weight loss and survival in severe A/PR/8/34 (H1N1) virus infections compared to WT counterparts. Likewise, lung dysfunction, histopathological damage, viral titers, and inflammatory cytokine levels were similar in the two groups. Global transcriptomic analysis also revealed similar inflammatory and antiviral gene expression programs in WT versus Gsdme ^-/- mouse lungs at baseline and in response to infection. To confi

SUBMITTER: Speaks S 

PROVIDER: S-EPMC12324273 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature