Targeting <i>Tmem63b</i> and <i>Piezo2</i> in C-fiber low threshold mechanoreceptor: limitation of <i>Vglut3</i>-IRES-<i>Cre</i>.

ABSTRACT: Peripheral somatosensory neurons in the dorsal root ganglia (DRG) transduce mechanical force in the skin and other organs into electrical signals using specialized mechanically activated (MA) ion channels that initiate neuronal activation in response to force. Increasing evidence highlights PIEZO2 as the primary transducer of low-threshold mechanical force in DRG neurons. However, in the absence of Piezo2, mice and humans still respond to noxious painful stimuli like pinch, suggesting that additional MA channel(s) likely exist in DRG neurons. Strategies to identify Cre lines and DRG subpopulations that select for non-PIEZO2 expressing neurons is therefore an ongoing effort in the field to discover unknown mechanosensors. Here, we investigated a Vglut3 labeled mouse lin

SUBMITTER: Orlin DJ 

PROVIDER: S-EPMC12324310 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature