Sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.

ABSTRACT: Sleep supports a variety of physiological processes, ranging from metabolic to immune system homeostasis, and plays a critical role in cognition and memory. A brief period of sleep loss impairs memory, particularly hippocampus-dependent memories, and alters molecular signaling and synaptic plasticity in the hippocampus. Studies have shown that sleep deprivation (SLD) alters neuronal activation as indicated by broad changes in gene expression signatures and by the altered expression of c-Fos, an immediate early gene (IEG) that functions as a molecular marker of neuronal activity. In the present study, we examined hippocampal subregion-specific c-Fos induction patterns. We find that CA1 pyramidal neurons exhibit the most robust c-Fos induction after SLD. Within CA1, the proximal region, wher

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12324322 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature