A Novel Phosphatase Reverses the Leloir Pathway to Promote Tagatose Synthesis from Glucose.

ABSTRACT: d-Tagatose is a natural, low-calorie, rare monosaccharide that has gained substantial interest as an alternative sweetener. It offers numerous benefits, including a low glycemic index, prebiotic properties, and the ability to lower blood sugar levels. Currently, tagatose is primarily produced industrially through the isomerization of galactose, utilizing both chemical and enzymatic catalysis. While these established processes can produce tagatose, they are inefficient and expensive. Recent works have demonstrated alternative biosynthetic routes to produce d-tagatose but suffer from low theoretical yield and/or reliance on expensive feedstocks. This study demonstrates a novel biochemical pathway to produce d-tagatose directly from glucose using a whole-cell process with Escherichia coli<

SUBMITTER: Love AM 

PROVIDER: S-EPMC12324327 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature