Sigma-1 Receptor Promotes Glycolysis in Neuronal Systems by Suppressing GRIM19.

ABSTRACT: Sigma-1 receptor (S1R) is a Ca²⁺ sensitive, ligand-operated receptor chaperone protein present on the endoplasmic reticulum (ER) membrane and more specifically at the mitochondria-associated ER membrane (MAM). Upon activation by ER calcium depletion or ligand binding, S1R can increase calcium efflux from the ER into the mitochondria by chaperoning IP3 receptor type3 (Ip3R3). Mitochondrial metabolism has an intricate relationship with glycolysis. Despite S1R affecting mitochondria, the relevance of S1R to glycolysis and its impact on the overall cellular energy metabolism is not known. This study utilizes wild-type (Wt) and S1R knockout (S1R KO) Neuro2a (N2a) cells and Wt and S1R KO mice for primary culture of cortical neurons studies and longitudinal in-vivo imaging. In t

SUBMITTER: Couly S 

PROVIDER: S-EPMC12324332 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature