Investigating the role of long non-coding RNA in hypertrophic cardiomyopathy.

ABSTRACT: Long non-coding RNA (lncRNA) are transcripts that do not typically code for protein but have essential roles in the regulation of transcription and translation in health and disease. The objective of this study was to identify potential lncRNAs that could play a role in the pathophysiology of hypertrophic cardiomyopathy (HCM). We analyzed RNA-Seq data for lncRNA expression from a mouse model of HCM and cross-referenced transcripts to a published human HCM tissue dataset. We identified a total of 9,140 lncRNA transcripts in the mouse dataset, of which 35 were differentially expressed between transgenic TNNT2 Δ160 mice (TG) and non-transgenic mice (nTG, p-adj < 0.05). Of these, 13 had a human ortholog as predicted by ortho2align. We used the computational tools MiPepid,

SUBMITTER: Branscom GA 

PROVIDER: S-EPMC12324334 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature