Condition-dependent effects of knockdown of autophagy on <i>C. elegans</i> longevity.

ABSTRACT: Autophagy is thought to clear damaged cellular constituents that contribute to aging, and several life-extending interventions in model organisms show some degree of autophagy dependence. In C. elegans, inhibiting autophagy can shorten, lengthen or have no effect on lifespan. Differences between published findings likely reflect variability in experimental conditions. Here we investigate the condition dependence of effects on lifespan of RNA-mediated interference (RNAi) knockdown of autophagy pathway components. Effects on several interventions causing a strong Age (increased lifespan) phenotype were examined, including mutation of daf-2 (insulin/IGF-1 receptor). Factors varied included daf-2 mutant allele class, atg gene, temperature and presence of 5-fluoro-2'

SUBMITTER: Hsiung KC 

PROVIDER: S-EPMC12324348 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature