Glucose Metabolism echoes Long-Range Temporal Correlations in the Human Brain.

ABSTRACT: Intrinsic brain activity is characterized by pervasive long-range temporal correlations. While these scale-invariant dynamics are a fundamental hallmark of brain function, their implications for individual-level metabolic regulation remain poorly understood. Here, we address this gap by integrating resting-state functional Magnetic Resonance Imaging (fMRI) and dynamic [¹⁸F]FDG Positron Emission Tomography (PET) data acquired from the same cohort of participants. We uncover a systematic relationship between long-range temporal correlations, quantified via the Hurst exponent, and glucose metabolism. Our findings reveal that persistent temporal dependencies impose a measurable metabolic cost, with brains exhibiting higher long-range temporal correlations incurring greater energetic

SUBMITTER: Facca M 

PROVIDER: S-EPMC12324358 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature