Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.

ABSTRACT: The human immune system undergoes continuous remodeling from infancy through old age, yet the timing and trajectory of these changes across the lifespan remain poorly defined. To address this, we profiled peripheral blood mononuclear cells from 95 healthy individuals (ages 2 months to 88 years), including infants (n=27), children (n=23), adults (n=18), and older adults (n=27) using scRNA-seq and snATAC-seq. MAIT and γδ T cells showed a "Rise and fall" pattern, which rise in childhood, peak in young adulthood, and decline with age. CD8⁺ T cells were the most affected by aging with decreasing naïve T cells and increasing GzK⁺ CD8⁺ T cells and TEMRA cells. Infants had lower myeloid/lymphoid ratio, with a distinct composition marked by increased frequencies of

SUBMITTER: Nehar-Belaid D 

PROVIDER: S-EPMC12324397 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature