The <i>piggyBac</i> derived transposase 5 (PGBD5) can interact with human <i>piggyBac</i>-like elements.

ABSTRACT: PGBD5 is encoded by a gene domesticated at the chordate origin from a DNA transposon of the piggyBac family. During its evolution, PGBD5's sequence has been under strong purifying selection among vertebrate genomes. This suggests PGBD5 functions in the development and physiology of chordates, as recently demonstrated in mouse and human brain development, where it was implicated in double strand DNA breaks on neurons. However, biochemical PGBD5 activities remain undefined due to lack of appropriate in vitro model systems. Furthermore, coevolution of PGBD5 with hosts has likely reshaped some of its functions, resulting in differences between vertebrate PGBD5 and the insect piggybac transposase (PB). Recent studies have found that PGBD5 can interact with two different "species"

SUBMITTER: Beauclair L 

PROVIDER: S-EPMC12324416 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature