Feature-specific inhibitory connectivity augments the accuracy of cortical representations.

ABSTRACT: To interpret complex sensory scenes, animals exploit statistical regularities to infer missing features and suppress redundant or ambiguous information. Cortical microcircuits might contribute to this cognitive goal by either completing or cancelling predictable activity, but it remains unknown whether, and how, a single circuit can implement these antagonistic computations. To address this central question, we used all-optical physiology to simulate sensory-evoked activity patterns in pyramidal cells (PCs) and somatostatin interneurons (SSTs) in the mouse's primary visual cortex (V1). In the absence of external visual input, photostimulation of orientation-tuned PC ensembles drove either completion or cancelation of input-matching representations, depending on the number of photostimulate

SUBMITTER: Ogando MB 

PROVIDER: S-EPMC12324542 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature