Metabolic factors associated with plasma phosphorylated tau analytes used to detect Alzheimer's disease pathology.

ABSTRACT:

Introduction

The interpretation of plasma phosphorylated tau (pTau) levels may be influenced by metabolic conditions, such as insulin resistance (IR), type 2 diabetes mellitus (T2DM), obesity, and kidney function. We examined the extent to which metabolic factors are associated with plasma pTau concentrations (pTau181, pTau217, pTau231) and the contribution of these factors on analytical outcomes.

Methods

We analyzed data from 287 participants using partial Spearman's rho, Mann Whitney U, ROC analysis, and linear mixed models.

Results

Concordance between plasma pTau217 and amyloid PET was not influenced by IR or estimated-glomerular-filtration-rate (eGFR). Accounting for eGFR improved concordance of pTau181 and pTau231 with amyloid PET. Age, binarized waist-to-hip rat

SUBMITTER: Yang KL 

PROVIDER: S-EPMC12324621 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature