Associations between obstructive sleep apnea and comorbidities in a large clinical biobank.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is associated with a wide range of comorbidities, but large-scale phenome-wide analyses in clinical biobanks remain under-reported. In this study, we identified common comorbidities enriched in patients with OSA, tested the temporality of these associations, and analyzed relevant associations with summary sleep recording data.

Methods

48,251 participants with OSA in the Mass General Brigham healthcare system were identified using a natural language processing phenotyping algorithm and/or evidence of an elevated apnea-hypopnea index (AHI). Controls were matched (2:1) on demographics, body mass index (BMI), and healthcare utilization. Associations with 358 incident and 563 cross-sectional diseases were tested using Modified Poisson regr

SUBMITTER: Cade BE 

PROVIDER: S-EPMC12324622 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature