Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap with metabolic markers.

ABSTRACT: Metabolic dysfunction is increasingly implicated in neurodegenerative diseases, yet the genetic architecture linking metabolic markers with Alzheimer's disease (AD) and Parkinson's disease (PD) remains unclear. We systematically analysed phenotypic and genetic relationships between 249 circulating metabolites with AD and PD, comparing patterns to body mass index (BMI), type 2 diabetes (T2D), coronary artery disease (CAD) and stroke. Using linkage disequilibrium score regression and bivariate Gaussian mixture modeling, we identified distinct genetic overlap. AD correlated positively with cardiometabolic traits (BMI, r _s =0.11; T2D, r _s =0.23; CAD, r _s =0.22; stroke, r _s =0.18), whereas PD showed opposing patterns (AD-PD r _s =-0.36). Men

SUBMITTER: Stinson SE 

PROVIDER: S-EPMC12324630 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature