Distinct Neurodevelopmental Signatures of Sex-Specific Transcriptome-Based Polygenic Risk Scores for Depression.

ABSTRACT: Major depressive disorder (MDD) impacts females and males differently and post-mortem gene expression profiling reveals distinct transcriptomic signatures of the disorder in each sex. Using genes that are transcriptionally altered in MDD in both sexes, we recently developed a novel transcriptome-based polygenic risk score (tPRS), which had sex-specific associations with brain structure and depressive symptoms in both adolescents and adults. Identifying the neurodevelopmental signatures of genetically-induced shifts toward a depression-like brain transcriptome in each sex during a crucial stage, when sex differences in MDD vulnerability initially manifest, could provide useful information about the developmental pathways of early MDD risk. Leveraging sex-specific MDD gene expression data, w

SUBMITTER: Rashid SS 

PROVIDER: S-EPMC12324647 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature