Resting-state functional connectivity alterations in obsessive-compulsive disorder: relationships between connectivity and clinical profiles in the Global OCD study.

ABSTRACT: Background Obsessive-compulsive disorder (OCD) has been associated with altered resting-state functional connectivity (FC), but findings are inconsistent and associations with clinical characteristics are unclear. The Global OCD study collected harmonized imaging, demographic, and clinical data across five sites and continents, with the aim of identifying consistent OCD-related alterations in FC. Methods We included 263 unmedicated adults with OCD and 254 healthy controls (HC) and estimated FC from resting-state functional magnetic resonance imaging. Between-group differences in and associations of clinical characteristics with FC were analyzed through general linear models adjusted for sex, age and years of education. We investigated seed-based FC of the amygdala, posterior putamen, nucle

SUBMITTER: Thorsen AL 

PROVIDER: S-EPMC12324664 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature