Estimation of Lassa fever incidence rates in West Africa: Development of a modeling framework to inform vaccine trial design.

ABSTRACT:

Background

Lassa fever (LF) is an acute viral hemorrhagic disease endemic to West Africa that has been declared a priority disease by the World Health Organization due to its severity and the lack of a vaccine or effective treatment options. Several candidate vaccines are currently in development and are expected to be ready for phase III field efficacy trials soon. However, most LF cases and deaths are believed to go unreported, and as a result we lack a clear understanding of several aspects of LF epidemiology and immunology that are critical to the design of vaccine efficacy trials.

Methods

To help guide vaccine trial design and trial site selection we estimated the force of infection (FOI) from rodent hosts to humans in all 1st and 2nd administrative units in West Africa

SUBMITTER: Moore SM 

PROVIDER: S-EPMC12324683 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature