Liquid Crystal Microcavity Biosensors for Real-Time Liver Injury Monitoring via Whispering Gallery Mode Laser.

ABSTRACT: Real-time monitoring of liver injury is essential for preserving physiological health. Alanine aminotransferase (ALT) detection is widely regarded as a fundamental approach for the early diagnosis of liver injury. However, existing detection methods often suffer from complex operation, high costs, and limited sensitivity. Here, we introduce a real-time biosensor based on functionalized liquid crystal microcavities with whispering gallery mode (WGM) laser for rapid and sensitive ALT detection. The microcavity functionalized with stearic acid exhibits distinct optical responses to ALT-catalyzed enzymatic reactions across varying concentrations. The high-quality factor of the microcavity obviously enhances its biosensing performance. Simulations reveal variations in the electric field behavio

SUBMITTER: Wang J 

PROVIDER: S-EPMC12324788 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature