Optimal QT Correction Formula for Older Chinese: Guangzhou Biobank Cohort Study.

ABSTRACT:

Introduction

To identify the optimal QT correction formula for generating corrected QT (QTc) and cutoffs for prolonged QTc, and examine the associations with mortality and cardiovascular disease (CVD) in older Chinese.

Methods

A prospective study included 24,611 Chinese aged 50+ years and without CVD at 2003-2008 from Guangzhou Biobank Cohort Study. QT interval was corrected by Bazett, Fridericia, Framingham and Hodges formulas. The slope and R2 of the QTc and heart rate regression were used to determine the optimal correction formula. The 95th percentile of QTc was used to defined prolonged QTc. Cox regression was used to examine associations of prolonged QTc with mortality and CVD. The net reclassification index was calculated to assess risk reclassification.

Results

SUBMITTER: Tian WB 

PROVIDER: S-EPMC12324792 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature