Assessment of Coronary Microvascular Dysfunction by Angiography-Based Index of Microcirculatory Resistance: An Indirect Meta-Analysis.

ABSTRACT:

Introduction

There is a lack of consensus on diagnosing coronary microvascular dysfunction (CMD) using the angiography-based index of microcirculatory resistance (Angio-IMR) due to the absence of evidence. This study aimed to explore the efficacy of Angio-IMR in diagnosing CMD.

Methods

A systematic search was conducted in PubMed, Embase, Scopus, and the Cochrane Library for studies primarily focusing on Angio-IMR diagnosing CMD, using IMR as the gold standard. The primary results were pooled sensitivity, specificity, and the area under the curve (AUC).

Results

A total of 15 studies involving 2,202 individuals and 2,330 vessels were included in our study, Angio-IMR demonstrated high performance in predicting IMR with overall pooled sensitivity and specificity of 0.84 (

SUBMITTER: Wen W 

PROVIDER: S-EPMC12324804 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature