Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27⁺IgD⁺ Unswitched Memory B Cell Profiles.

ABSTRACT: Objectives: Over the past decades, the prevalence of noncommunicable diseases has surged significantly, including the systemic autoimmune disorder rheumatoid arthritis (RA). Despite extensive research and advancement of RA therapy, effective prevention strategies or cures remain elusive, and the mechanisms underlying RA pathogenesis unclear. It is crucial to gain deeper insights into RA pathophysiology. The objective of this study is to provide a comprehensive immunophenotyping of patients with RA. Methods: We generated and analyzed deep immunophenotyping data from 52 patients with RA and 47 healthy controls (HCs). Whole blood samples were stained with extracellular markers, and intracellular antibodies and analyzed for 32 different cell markers using mass cytometry by time o

SUBMITTER: Hansen B 

PROVIDER: S-EPMC12324914 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature