Effect of Particulate Matter in Atopic Dermatitis through HDACs and Filaggrin Alteration.

ABSTRACT: Atopic dermatitis (AD) is a skin condition that can be exacerbated by particulate matter (PM). The primary causes of AD are believed to be impairments in the skin barrier, such as filaggrin (FLG) abnormalities. Although there is substantial evidence for genetic factors contributing to AD, it is challenging to attribute the disease's predisposition solely to genetics. We hypothesize that PM may induce epigenetic modifications in AD, impacting FLG expression. Here, we assessed histone deacetylases (HDACs) and FLG levels under AD conditions with or without exposure to PM using qRT-PCR, western blotting, and immunofluorescence. Additionally, we observed changes in these molecules when co-treated with the HDAC inhibitor, trichostatin A (TSA). FLG levels tended to decrease when PM or IL-4/13 wer

SUBMITTER: Roh YJ 

PROVIDER: S-EPMC12324990 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature