Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers.

ABSTRACT: HemoHIM is a mixed extract derived from the roots of oriental medicinal herbs. Despite many studies on HemoHIM's antioxidant properties and its effect on immune functions, fatigue reduction, and exercise performance, published data regarding its physiological safety in humans are lacking. Therefore, this study aimed to investigate the safety profile of HemoHIM in humans. The samples were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with ultra-high-performance LC coupled to an Orbitrap MS. Data processing and compound identification were performed through nontargeted screening using multiple spectral databases. Ninety-six healthy adults were recruited in the clinical study. On visit 1, screening was conducted to assess eligibility. On visit 2, participants were r

SUBMITTER: Seo JW 

PROVIDER: S-EPMC12324994 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature