Longitudinal Analysis of the Immunostimulatory Properties and Safety Profile of <i>Lacticaseibacillus rhamnosus</i> LRa05 as a Dietary Supplement.

ABSTRACT: Supplementation with appropriate doses of Lacticaseibacillus rhamnosus has been reported to potentially attenuate immune changes. While some progress has been made in studying the immune function of L. rhamnosus LRa05, a lack of systematic summaries has led to the neglect of its application in enhancing immune function. This study aimed to investigate the effects of L. rhamnosus LRa05 on the immune function of mice and to evaluate its safety profile as a dietary supplement. Mice were divided into three dosage groups (0.205, 0.410, and 1.230 g/kg body weight [BW]) and a negative control group (PBS), with each group orally gavaged for 30 consecutive days. The study assessed body weight, organ-to-body weight ratio, cellular immune function, humoral immune function, monocy

SUBMITTER: Wu J 

PROVIDER: S-EPMC12324998 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature