Weight-adjusted waist circumference index and chronic diseases as predictors of depression risk in U.S. adults: a cross-sectional study with mediation analysis.

ABSTRACT:

Objective

This study aimed to examine the association between the weight-adjusted waist circumference index (WWI) and the risk of depression in U.S. adults, as well as the potential mediating roles of chronic diseases (hypertension, diabetes, stroke, and coronary heart disease) in this relationship.

Methods

Data from 7,709 adults aged 20-80 years in the 2017-2023 National Health and Nutrition Examination Survey (NHANES) were analyzed. Logistic regression was used to assess the relationships between WWI (both continuous and categorical) and chronic diseases with depression risk, adjusting for confounders. Subgroup analyses were conducted based on age, sex, race, PIR, education level, marital status, smoking, and drinking status. A restricted cubic spline (RCS) analysis was pe

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12325032 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature