Genetic variants in <i>HLA-DQA1/DQB1</i> genes modulate the risk of gestational diabetes mellitus in a southern Chinese population.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is an endocrine disorder that occurs easily in women during pregnancy. HLA-DQA1/DQB1 genes play a crucial role in the regulation of the human immune and endocrine systems, potentially influencing the pathogenesis of GDM.

Objective

To explore the associations between single nucleotide polymorphisms (SNPs) in HLA-DQA1/DQB1 genes and the risk of GDM.

Methods

Seven functional SNPs of HLA-DQA1/DQB1 genes were selected and genotyped in 523 GDM patients and 638 normal pregnant women. The odds ratio (OR) and its corresponding 95% confidence interval (CI) were utilized to assess the association between candidate SNPs and the risk of GDM. And then, false positive report probability (FPRP), multifactor dimension

SUBMITTER: Nie L 

PROVIDER: S-EPMC12325038 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature