Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis.

ABSTRACT:

Background

Male-related factors contribute to 30-40% of infertility cases, with donor sperm serving as a critical solution for severe male infertility or paternally inherited genetic disorders. While cryopreservation ensures virological safety, concerns persist regarding sperm DNA damage, oxidative stress, and epigenetic impacts on embryogenesis. Previous studies have shown inconsistent evidence regarding obstetric and perinatal outcomes using donor versus partner sperm. This meta-analysis aimed to compare these outcomes to guide evidence-based clinical decisions.

Methods

To identify studies published up to December 2024, we systematically search Embase, PubMed, Scopus, Wanfang, Web of Science, and China National Knowledge Infrastructure (CNKI). Studies investigating obstetr

SUBMITTER: Liu J 

PROVIDER: S-EPMC12325047 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature