Genetic prediction of the casual relationship between micronutrients and ER+ breast cancer: a Mendelian randomized study.

ABSTRACT:

Background

Estrogen receptor-positive (ER+) breast cancer, a prevalent subtype of breast malignancy, demonstrates complex etiological associations with multiple risk factors. Micronutrients, as essential nutritional components for human physiology, may potentially influence the pathogenesis and progression of breast carcinoma. This investigation employs Mendelian randomization (MR) methodology to assess causal relationships between 15 micronutrients and ER+ breast cancer.

Methods

In this study, instrumental variables (IVs) for 15 micronutrients were extracted from the genome-wide association studies (GWAS) database, including copper, calcium, carotene, folate, iron, magnesium, potassium, selenium, vitamin A, vitamin B12, vitamin B6, vitamin C, vitamin D, vitamin E, and zinc.

SUBMITTER: Fu WD 

PROVIDER: S-EPMC12325068 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature