Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies.

ABSTRACT:

Introduction

Ultrasound-based staging systems for twin-twin transfusion syndrome (TTTS) are limited by radiologic expertise, fetal positioning, and timing of the exam, and may benefit from incorporation of objective biochemical measures for diagnosis and prognostication. microRNA expression is altered in amniotic fluid of TTTS patients, however the invasive nature of amniocentesis has precluded practical incorporation of these biomarkers into current staging systems. Therefore, we sought to assess whether non-invasive maternal plasma microRNAs can distinguish between TTTS and normal monochorionic diamniotic (MCDA) twin pregnancies.

Methods

Maternal blood samples were collected for patients with normal MCDA twin pregnancies (n = 11) or prior to selective fetoscopic laser phot

SUBMITTER: Papastefan ST 

PROVIDER: S-EPMC12325072 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature