Reinstating respiratory heart rate variability improves hemodynamic responses during exercise in heart failure with reduced ejection fraction.

ABSTRACT: Individuals with heart failure have significantly reduced exercise capacity, a critical life-limiting symptom for those living with the disease. Heart failure is negatively correlated with decreased heart rate variability, including the loss of heart rate variability in tune with breathing-termed respiratory heart rate variability (RespHRV). We tested the hypothesis that restoration of RespHRV would improve exercise tolerance. Heart failure was induced in adult female sheep using a microembolization technique, and the sheep were divided into two groups: RespHRV paced and monotonically paced. Following a 1-week baseline recording, the sheep underwent 2 weeks of pacing. Direct recordings of hemodynamic parameters, including arterial pressure, cardiac output, coronary artery blood flow, and h

SUBMITTER: Shanks J 

PROVIDER: S-EPMC12325447 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature