Sex differences in schizophrenia spectrum disorders: insights from the DiAPAson study using a data-driven approach.

ABSTRACT:

Purpose

Schizophrenia Spectrum Disorders (SSD) display notable sex differences: males have an earlier onset and more severe negative symptoms, while females exhibit affective symptoms, better verbal abilities, and a more favourable prognosis. Despite extensive research, areas such as time perception and positivity remain underexplored, and machine learning has not yet been adequately utilised. This study aims to address these gaps by examining sex differences in a sample of Italian patients with SSD using a data-driven approach.

Methods

As part of the DiAPAson project, 619 Italian patients with SSD (198 females; 421 males) were assessed using standardised clinical tools. Data on socio-demographics, clinical characteristics, symptom severity, functioning, positivity, quality

SUBMITTER: Martinelli A 

PROVIDER: S-EPMC12325527 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature