Therapeutic strategies for low anterior resection syndrome: an umbrella review of systematic reviews.

ABSTRACT:

Purpose

The purpose of this umbrella review was to systematically evaluate the effectiveness of therapeutic strategies for managing low anterior resection syndrome following sphincter-preserving surgery for rectal cancer and to provide evidence-based recommendations for clinical practice.

Methods

A systematic literature search was performed across five electronic databases. Two independent reviewers screened titles/abstracts, assessed full-text studies, and extracted data, with discrepancies resolved by consensus. The study adhered to AMSTAR-2 and GRADE frameworks for methodological quality and evidence certainty assessments.

Results

Sixteen systematic reviews (including nine meta-analyses) published between 2018 and 2025 were analyzed, covering therapeutic strategies

SUBMITTER: Liu T 

PROVIDER: S-EPMC12325548 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature