Phage-mediated TLR2 signaling attenuates intracellular Mycobacterium abscessus survival in macrophages.

ABSTRACT: The incidence of pulmonary infections caused by M. abscessus (MAB) is on rise globally. Despite susceptible infections, long-term, and combinational treatment, patients respond to MAB therapy only partially with low success rates. In recent years, therapeutic phages have been used in combination with antibiotics to enhance treatments for patients suffering with drug-resistant, chronic, and disseminated mycobacterial infections with favorable clinical outcomes. While phages are commonly recognized for their antimicrobial role through direct lysis of bacteria, expanding body of literature, describing phage interactions with the immune system, indicates that the therapeutic impact of phage may not solely hinge on lytic activity but also on stimulating innate immune responses. In this study, w

SUBMITTER: Kapoor H 

PROVIDER: S-EPMC12325590 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature