Analysis of the prognostic and immune role of MCM6 in pan-cancer and experimental validation in lung adenocarcinoma cells.

ABSTRACT: Mini-chromosome maintenance protein 6 (MCM6), a member of the DNA replication initiation complex, is considered a potential prognostic marker for multiple tumors. However, the biological role of MCM6 has not been reported in pan-cancer. In present study, a pan-cancer analysis of MCM6 was performed using multiple databases and online websites. The relationship between MCM6 and DNA methylation, prognosis, immune infiltration and immunotherapy response was investigated. Weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) Cox regression models were performed to construct prognostic risk signature for lung adenocarcinoma (LUAD) based on MCM6-related cell cycle genes (MrCCGs). Meanwhile, the biological function of MCM6 in lung adenocar

SUBMITTER: Liao M 

PROVIDER: S-EPMC12325616 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature