Revealing inhibitory activity of luteolin from Vietnamese Jatropha Podagrica Hook against Staphylococcus aureus by integrating in vitro and in silico approaches.

ABSTRACT: Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are increasingly prevalent pathogens associated with multidrug-resistant infections in both hospital and community. In this study, we evaluated the antibacterial activity of Jatropha podagrica Hook. extracts collected from Vietnam against S. aureus and MRSA. Among various plant parts, the root extract exhibited the most potent activity, with an MBC/MIC ratio of 2.0, indicating bactericidal properties. To elucidate the mechanism of action and identify potential bioactive constituents, a virtual screening of 43 phytochemicals from J. podagrica was performed against sortase A (SrtA), a key virulence factor of S. aureus, using molecular docking. Among them, luteolin demonstrated the highest binding affinity (ΔG = - 9.

SUBMITTER: Tran MH 

PROVIDER: S-EPMC12325669 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature