NF-κB inactivation in myeloid cell leads to reprogramming of whole-body energy metabolism in response to high-fat diet.

ABSTRACT: Energy metabolism is subject to reprogramming in the body upon bacterial or virus infection. It is generally believed that immune cells sense the stress signals of infection to mediate the reprogramming of whole-body energy metabolism. However, the key molecules required for the immune cell function remain to be identified. In this study, we addressed the issue by examining the energy metabolism in Lyz2-p65-KO mice, in which p65 (RelA) gene is inactivated in myeloid cells. On Chow diet, the p65-KO mice exhibited no difference to the wild type mice in the energy metabolism. On a high fat diet (HFD), the KO mice gained less adipose tissue and body weight for improved insulin sensitivity and blood lipids along reduction in pro-inflammatory cytokine. This was observed with more energy loss in

SUBMITTER: Wang X 

PROVIDER: S-EPMC12325682 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature