Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy.

ABSTRACT: Osseointegration for implants, especially bioinert implants, poses significant clinical challenges. Overcoming fibrotic encapsulation and promoting osseointegration at the implant interface are critical for successful bone repair, which highly expected biomaterials with osteoblast over fibroblast selectivity. However, few materials possess the function. β-amino acid polymers have demonstrated cell adhesion property, easy preparation, and robust stability to resist proteolysis as emerging biomaterials. Here, we develop amphiphilic β-amino acid polymers that demonstrate exceptional osteoblast vs fibroblast selectivity, outperforming the natural osteoblast-selective KRSR peptide. The optimal polymer selectively supports osteoblast adhesion by manipulating the adsorption of serum proteins and

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12325762 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature