A novel cuproptosis-related genes nomogram on the prognosis and immune microenvironment of breast invasive carcinoma.

ABSTRACT: Explore the relationship between breast invasive carcinoma (BRCA) and cuproptosis-related genes (CRGs). CRGs related to prognosis were calculated using Lasso analysis and multivariate Cox analysis based on BRCA data from the TCGA, CRG signatures were then generated to categorize patients based on their risk scores into high-risk and low-risk categories. The GEO dataset was used as external validation. A nomogram was constructed in order to further predict the survival of patients. We also examined differences in the infiltrative status of immune cell subsets present between the high-risk and low-risk categories. The prognostic gene expression were validated utilizing real-time quantitative PCR (RT-qPCR). We identified nine CRGs associated with survival and built a risk model to separate pa

SUBMITTER: Shang G 

PROVIDER: S-EPMC12325781 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature