Exploring the causal relationship between hemoglobin and pancreatic cancer and its potential mechanisms through bioinformatics and Mendelian randomization.

ABSTRACT:

Background

Abnormal hemoglobin (HGB) levels and the onset of malignant tumors have attracted substantial clinical interest. PAAD, a highly fatal malignancy of the digestive system, warrants further investigation regarding its potential link with HGB levels. To explore the genetic relationship between the two, we employed Mendelian randomization in conjunction with transcriptomic analysis to probe their underlying connection.

Methods

A combined approach utilizing Mendelian randomization (MR) and transcriptomics was adopted to examine the genetic association between HGB levels and PAAD, along with possible mechanistic pathways. Based on GWAS datasets derived from European populations, MR analysis was conducted to evaluate the causal relationship between HGB levels and the risk

SUBMITTER: Wang S 

PROVIDER: S-EPMC12325827 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature