Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning.

ABSTRACT: Goal-directed learning arises from distributed neural circuits including the prefrontal, posterior parietal and temporal cortices. However, the role of cortico-cortical functional interactions remains unclear. To address this question, we integrated information dynamics analysis with magnetoencephalography to investigate the encoding of learning signals through neural interactions. Our findings revealed that information gain (the reduction in uncertainty about the causal relationship between actions and outcomes) is represented over the visual, parietal, lateral prefrontal and ventromedial/orbital prefrontal cortices. Cortico-cortical interactions encoded information gain synergistically at the level of pairwise and higher-order relations, such as triplets and quadruplets. Higher-order syn

SUBMITTER: Combrisson E 

PROVIDER: S-EPMC12325950 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature