Personalised bactericidal combination regimens against carbapenem-resistant Pseudomonas aeruginosa.

ABSTRACT:

Background

Limited treatment options are available for carbapenem-resistant Pseudomonas aeruginosa (CRPA), especially those harbouring carbapenemases. Given the variability in effectiveness of antibiotic combinations, in vitro test-guided antibiotic therapies have been suggested to improve the outcomes of patients receiving combination therapy. We investigated the in vitro bactericidal activities of various combinations against CRPA and described our experience of using a personalised test-guided approach in managing these difficult-to-treat infections.

Methods

In vitro antibiotic combination tests (iACTs) comprising up to 180 unique combinations at clinically relevant unbound concentrations were performed for CRPA isolates collected for a monocentric prospective cohort stud

SUBMITTER: Teo JQ 

PROVIDER: S-EPMC12325961 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature