Evaluation of FASTinov for rapid antimicrobial susceptibility testing in Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa is a critical priority pathogen due to its high resistance rates and limited treatment options. Rapid antimicrobial susceptibility testing (rAST) is essential to optimize therapy, particularly because resistance mechanisms in P. aeruginosa often arise from adaptive genetic expression rather than specific resistance genes. FASTinov, a flow cytometry-based rAST system, was developed to address this challenge by providing phenotypic susceptibility results within hours. In this study, we assessed FASTinov's performance for rapid antimicrobial susceptibility testing (rAST) in 100 P. aeruginosa strains, using broth microdilution as the reference method. For clinical relevance, we also included the MicroScan WalkAway system as a comparator. FASTinov demonstrated a categoric

SUBMITTER: Cintora-Mairal C 

PROVIDER: S-EPMC12325984 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature