Identification of gene-sun exposure interactions of GWAS-identified variants in perceived facial aging progression.

ABSTRACT:

Background

Skin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders. While both environmental and genetic factors contribute to these changes, their interaction remains underexplored. Perceived age is a biomarker of health and strongly related to facial skin aging features. Thus, we conducted a gene-environment interaction analysis on the perceived facial aging progression phenotype in 226 women, focusing on sun exposure as the environmental factor.

Methods

We assessed perceived age in 226 women at two time points, 12 years apart, allowing defining a perceived facial aging progression as phenotype. We applied a two-step gene-environment inte

SUBMITTER: Obry L 

PROVIDER: S-EPMC12326137 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature