Association of ZNF608 Polymorphisms With House Dust Mite-Induced Allergic Rhinitis.

ABSTRACT:

Background

Genetic factors contribute essentially to the pathophysiology of house dust mite (HDM)-induced allergic rhinitis. Previous studies mainly focused on the biological pathogenesis, but the heritability remains poorly explained.

Methods

A genome-wide gene association analysis (GWGAS) integrating joint-genetic variant effects at the gene level was initially conducted on allergic rhinitis, validated by differential gene expression analysis. A weighted polygenic risk score (wPRS) was used to proxy the cumulative effect of candidate genetic variants in key genes. Gene-set analysis and eQTL analysis were performed to explore the immunologic pathway and genetic regulation of the key gene.

Results

ZNF608 was identified as the key gene involving HDM-induced allergic rh

SUBMITTER: Li H 

PROVIDER: S-EPMC12326142 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature